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	Provedor de dados BABT (1) BJPS (1) Autor El-Naggar,Sabry Ali (2) El-Said,Karim Samy (2) Elbakry,Mohamed (1) Mobasher,Maysa (1) Palavra-chave Cisplatin (2) Antitumor (1) Ehrlich Ascites Carcinoma (1) Ehrlich ascites carcinoma (1) Ethylene diamine tetra-acetic acid (EDTA) (1) Ethylenediamine tetraacetic acid (EDTA)/Antitumor efficacy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2019 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antitumor efficacy of EDTA co-treatment with cisplatin in tumor-bearing mice BJPS El-Naggar,Sabry Ali; El-Said,Karim Samy. Ethylenediamine tetraacetic acid (EDTA) is used in various medical applications. The aim of this study is to investigate the antitumor efficacy of EDTA alone or with cisplatin (Cis). Fifty male albino mice were used to assess the median lethal dose (LD50) of EDTA via intraperitoneal (i.p) injection. To determine the antitumor activity, fifty female albino mice were divided into five groups as the following; Group 1 (Gp1) was negative control; (Gp2-5) inoculated i.p with 2×106 Ehrlich Ascites Carcinoma (EAC) cells/mouse. After one day, Gp3, Gp4 and Gp5 injected with Cis (2 mg/kg), EDTA (25 mg/kg) and Cis (2 mg/kg)/EDTA (25 mg/kg) for six days, respectively. At day 14, all groups were sacrificed to assess the tumor profile, liver enzymes (alanine... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cisplatin; Ethylenediamine tetraacetic acid (EDTA)/Antitumor efficacy; Ehrlich Ascites Carcinoma. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100571 Enhancing Antitumor Efficacy of Cisplatin Low Dose by EDTA in Ehrlich Ascetic Carcinoma Bearing Mice BABT El-Naggar,Sabry Ali; El-Said,Karim Samy; Mobasher,Maysa; Elbakry,Mohamed. Abstract In a recent study, the treatment of different human cancer cell lines in vitro with ethylene diamine tetra-acetic acid (EDTA) showed a promising anticancer activity which could be a novel promising approach for cancer treatment. The aim of this study is to address the ability of EDTA to enhance the antitumor efficacy of the low dose of cisplatin (Cis) treatment in Ehrlich ascetic carcinoma (EAC) bearing mice. Sixty female albino mice were divided into six groups. The 1st group of mice was served as a negative control. 2nd - 6th groups were inoculated intraperitoneal (i.p) with 2×106 EAC cells/mouse. After one day of inoculation, the 2nd, 3rd and 4th groups were injected daily for 6 days (early treatment) with phosphate buffer saline, low dose of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cisplatin; Antitumor; Ethylene diamine tetra-acetic acid (EDTA); Ehrlich ascites carcinoma. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100316 Registros recuperados: 2 Primeira ... 1 ... Última

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